Journal: Biomedical Reports
Article Title: Preliminary exploration of the role of CD8 + T cells in anti-PD-1 antibody-induced myocarditis in C57BL/6 mice with Lewis lung carcinoma
doi: 10.3892/br.2026.2129
Figure Lengend Snippet: Anti-PD-1 therapy improves the histopathology of lung and tumor tissue but induces myocarditis in wild-type mice. (A) Representative photographs of the lungs containing the tumors. HE staining was performed to examine the histopathology of (B) tumor (black arrow, nucleus; red arrow, inflammatory cell infiltration), (C) lung (arrow, interstitial congestion) and (D) heart tissue (black arrow, intercellular space; red arrow, inflammatory cell infiltration). (E) Masson's trichrome staining was performed to examine the histopathology of heart tissue. Arrow, collagen fiber. Scale bar, 50 µm. * P<0.05 vs. control, ### P<0.001 vs. LLC. HE, hematoxylin-eosin; LLC, Lewis lung carcinoma.
Article Snippet: Masson's trichrome (cat. no. C0189S) and hematoxylin & eosin (HE) staining kit (cat. no. C0105S) were purchased from Beyotime Institute of Biotechnology.
Techniques: Histopathology, Staining, Control